Vascular and hepatic enhancements at MR imaging: comparison of Gd-EOB-DTPA and Gd-DTPA in the same subjects

Clin Imaging. 2014 May-Jun;38(3):287-91. doi: 10.1016/j.clinimag.2014.01.001. Epub 2014 Jan 13.

Abstract

Objective: The objective was to compare vascular and hepatic enhancement differences at magnetic resonance imaging (MRI) between Gd-EOB-DTPA and Gd-DTPA in the same subjects.

Methods: Ten healthy subjects received dynamic contrast-enhanced MRI (DCE-MRI) with Gd-EOB-DTPA and then Gd-DTPA to obtain quantitative parameters at 60 and 100 s, respectively.

Results: At 60 s, no difference was noted in DCE-MRI parameters between the two contrast agents. At 100 s, mean transit time (MTT) was higher in Gd-EOB-DTPA than in Gd-DTPA (P=.008).

Conclusions: Gd-EOB-DTPA showed vascular and hepatic enhancement similar to Gd-DTPA within the initial 60 s during the dynamic phase, but showed increased MTT due to hepatocytes uptake at 100 s.

Keywords: DCE-MRI; Gd-DTPA; Gd-EOB-DTPA; Perfusion imaging.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Adult
  • Contrast Media*
  • Female
  • Gadolinium DTPA*
  • Hepatic Artery
  • Hepatic Veins
  • Humans
  • Image Enhancement / methods*
  • Liver / blood supply*
  • Liver / cytology*
  • Magnetic Resonance Angiography
  • Magnetic Resonance Imaging / methods*
  • Male
  • Middle Aged
  • Portal Vein

Substances

  • Contrast Media
  • gadolinium ethoxybenzyl DTPA
  • Gadolinium DTPA