Isolation of the plant hormone (+)-abscisic acid as an antimycobacterial constituent of the medicinal plant endophyte Nigrospora sp

Trevor N Clark; Katelyn Ellsworth; Haoxin Li; John A Johnson; Christopher A Gray

Isolation of the plant hormone (+)-abscisic acid as an antimycobacterial constituent of the medicinal plant endophyte Nigrospora sp

Nat Prod Commun. 2013 Dec;8(12):1673-4.

Authors

Trevor N Clark¹, Katelyn Ellsworth¹, Haoxin Li¹, John A Johnson¹, Christopher A Gray¹

Affiliation

¹ Department of Biology, University of New Brunswick, 100 Tucker Park Rd, Saint John, NB, Canada, E2L 4L5.

PMID: 24555269

Abstract

An extract of the endophytic fungus Nigropsora sp. (isolate TC2-054) from the Canadian medicinal plant Fragaria virginiana exhibited significant antimycobacterial activity against Mycobacterium tuberculosis H37Ra. Bioassay guided fractionation revealed that linoleic acid derivatives and the plant hormone (+)-abscisic acid (ABA) were responsible for the observed antimycobacterial activity. This activity of ABA has not been previously reported.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Abscisic Acid / isolation & purification*
Anti-Bacterial Agents / isolation & purification*
Antineoplastic Agents, Phytogenic / isolation & purification
Drug Screening Assays, Antitumor
Endophytes / chemistry*
Fragaria / microbiology*
HEK293 Cells
Humans
Microbial Sensitivity Tests
Plants, Medicinal / microbiology

Substances

Anti-Bacterial Agents
Antineoplastic Agents, Phytogenic
Abscisic Acid