Fluorescent probes for detecting monoamine oxidase activity and cell imaging

Org Biomol Chem. 2014 Apr 7;12(13):2033-6. doi: 10.1039/c3ob42326c. Epub 2014 Feb 20.

Abstract

A series of new fluorogenic probes for monoamine oxidases (MAOs) were reported based on an oxidation and β-elimination mechanism. The limits of detection of the probes for MAO-A and -B were determined to be 3.5 and 6.0 μg mL(-1) respectively. These probes displayed strong activity towards MAOs, especially MAO-B. Cellular imaging studies were also successfully conducted with MCF-7 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Enzyme Activation
  • Fluorescent Dyes / chemistry*
  • Humans
  • MCF-7 Cells
  • Molecular Structure
  • Monoamine Oxidase / analysis*
  • Monoamine Oxidase / metabolism
  • Xanthenes / chemistry*

Substances

  • Fluorescent Dyes
  • Xanthenes
  • Monoamine Oxidase