Dendron synthesis and carbohydrate immobilization on a biomaterial surface by a double-click reaction

Org Lett. 2014 Mar 7;16(5):1298-301. doi: 10.1021/ol403476z. Epub 2014 Feb 19.

Abstract

The synthesis of new dendrons and their immobilization on collagen patches via thiol-ene photoclick reaction, followed by chemoselective alkoxyamino-carbonyl conjugation to carbohydrates is presented. XPS, FTIR, and ELLA assays confirmed the effectiveness of the collagen multivalent neoglycosylation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbohydrates / chemistry*
  • Click Chemistry
  • Collagen / chemistry
  • Dendrimers / chemical synthesis*
  • Dendrimers / chemistry
  • Molecular Structure
  • Sulfhydryl Compounds / chemistry

Substances

  • Carbohydrates
  • Dendrimers
  • Sulfhydryl Compounds
  • Collagen