Abstract
Like varicella zoster virus in humans, simian varicella virus (SVV) becomes latent in ganglionic neurons along the entire neuraxis and reactivates in immunosuppressed monkeys. Five rhesus macaques were inoculated with SVV; 142 days later (latency), four monkeys were immunosuppressed, and T cells were analyzed for naïve, memory, and effector phenotypes and expression of programmed death receptor-1 (PD-1; T cell exhaustion). All T cell subsets decreased during immunosuppression and except for CD8 effectors, peaked 2 weeks before zoster. Compared to before immunosuppression, PD-1 expression increased at reactivation. Increased T cells before zoster is likely due to virus reactivation.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Aging / immunology
-
Animals
-
CD4-Positive T-Lymphocytes / immunology
-
CD4-Positive T-Lymphocytes / pathology
-
CD4-Positive T-Lymphocytes / virology*
-
CD8-Positive T-Lymphocytes / immunology
-
CD8-Positive T-Lymphocytes / pathology
-
CD8-Positive T-Lymphocytes / virology*
-
Glucocorticoids / pharmacology
-
Herpes Zoster / immunology*
-
Herpes Zoster / pathology
-
Herpesvirus 3, Human / immunology*
-
Immunologic Memory / immunology
-
Immunosuppressive Agents / pharmacology
-
Macaca mulatta
-
Prednisone / pharmacology
-
Programmed Cell Death 1 Receptor / immunology*
-
Virus Activation / immunology
Substances
-
Glucocorticoids
-
Immunosuppressive Agents
-
Programmed Cell Death 1 Receptor
-
Prednisone