Manganese(III)-mediated direct Csp2-H radical trifluoromethylation of coumarins with sodium trifluoromethanesulfinate

Chem Commun (Camb). 2014 Mar 28;50(25):3359-62. doi: 10.1039/c3cc49689a. Epub 2014 Feb 18.

Abstract

Mn(OAc)3-mediated direct Csp2-H radical trifluoromethylation of coumarins with CF3SO2Na (Langlois reagent) to afford selective 3-trifluoromethyl coumarins in moderate to good yields is described. This methodology can also be applied to the trifluoromethylation of quinolinones and pyrimidinones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Coumarins / chemistry*
  • Hydrocarbons, Fluorinated / chemistry*
  • Manganese / chemistry*
  • Mesylates / chemistry*

Substances

  • Coumarins
  • Hydrocarbons, Fluorinated
  • Mesylates
  • sodium trifluoromethanesulfinate
  • Manganese