miniMAVS, You Complete Me!

Manira Rayamajhi; Edward A Miao; Nathaniel J Moorman

doi:10.1016/j.cell.2014.01.045

miniMAVS, You Complete Me!

Cell. 2014 Feb 13;156(4):629-30. doi: 10.1016/j.cell.2014.01.045.

Authors

Manira Rayamajhi¹, Edward A Miao¹, Nathaniel J Moorman²

Affiliations

¹ Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
² Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: nathaniel_moorman@med.unc.edu.

Abstract

The functional significance of protein diversification through translational regulation in mammals is largely unexplored. Brubaker et al. now describe the generation of two functionally distinct mammalian proteins, MAVS and miniMAVS, from a single bicistronic mRNA and suggest that noncanonical translation may impact multiple players in innate immune regulation.

Publication types

Comment

MeSH terms

Adaptor Proteins, Signal Transducing / genetics*
Adaptor Proteins, Signal Transducing / immunology*
Animals
Gene Expression Regulation*
Humans
Immunity, Innate*
Protein Biosynthesis*

Substances

Adaptor Proteins, Signal Transducing
MAVS protein, human

Abstract

Publication types

MeSH terms

Substances

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