Abstract
Autoimmunity and chronic low-grade inflammation are hallmarks of diabetes mellitus type one (T1DM) and type two (T2DM), respectively. Both processes are orchestrated by inflammatory cytokines, including the macrophage migration inhibitory factor (MIF). To date, MIF has been implicated in both types of diabetes; therefore, understanding the role of MIF could affect our understanding of the autoimmune or inflammatory responses that influence diabetic pathology. This review highlights our current knowledge about the involvement of MIF in both types of diabetes in the clinical environment and in experimental disease models.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Diabetes Mellitus, Type 1 / etiology
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Diabetes Mellitus, Type 1 / immunology
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Diabetes Mellitus, Type 1 / metabolism*
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Diabetes Mellitus, Type 1 / physiopathology
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Diabetes Mellitus, Type 2 / etiology
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Diabetes Mellitus, Type 2 / immunology
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Diabetes Mellitus, Type 2 / metabolism*
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Diabetes Mellitus, Type 2 / physiopathology
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Disease Progression
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Humans
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Insulin / metabolism
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Insulin Secretion
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Insulin-Secreting Cells / immunology
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Insulin-Secreting Cells / metabolism
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Intramolecular Oxidoreductases / metabolism*
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Macrophage Migration-Inhibitory Factors / metabolism*
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Models, Biological*
Substances
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Insulin
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Macrophage Migration-Inhibitory Factors
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Intramolecular Oxidoreductases
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MIF protein, human