The contribution of assessing cognitive impairment in radiologically-isolated syndrome (RIS): a single case report follow-up study

Mult Scler. 2014 Dec;20(14):1912-5; discussion 1916-7. doi: 10.1177/1352458514523693. Epub 2014 Feb 13.

Abstract

Radiologically-isolated syndrome (RIS) is a recently-defined entity, described as the incidental discovery of lesions suggestive of multiple sclerosis (MS) on brain magnetic resonance imaging (MRI) scans demonstrating dissemination in space (DIS) without symptom expression and with a normal neurological examination. Recent studies demonstrate that RIS patients present similar features of cognitive impairment as MS patients. We describe a case of a RIS patient in whom investigating cognitive functions was a useful tool for diagnostic and therapeutic decisions.

Keywords: Brain lesions; case study; cognitive impairment; early treatment; multiple sclerosis; neuropsychological testing; radiologically-isolated syndrome.

Publication types

  • Case Reports

MeSH terms

  • Asymptomatic Diseases*
  • Brain / pathology*
  • Cervical Vertebrae
  • Cognition Disorders / diagnosis*
  • Cognition Disorders / psychology
  • Evoked Potentials, Visual
  • Female
  • Follow-Up Studies
  • Humans
  • Incidental Findings*
  • Magnetic Resonance Imaging
  • Middle Aged
  • Multiple Sclerosis / diagnosis*
  • Multiple Sclerosis / psychology
  • Neuropsychological Tests
  • Oligoclonal Bands / cerebrospinal fluid
  • Spinal Cord / pathology*

Substances

  • Oligoclonal Bands