Eosinophilic fasciitis as a paraneoplastic syndrome, a case report and review of the literature

Abstract

Eosinophilic fasciitis (EF) is a rare disease with characteristic clinical and histological features, previously reported to be associated with various hematological and solid malignancies. We report a typical case of eosinophilic fasciitis in a 67-year-old man in association with myelodysplastic syndromes (MDS)/acute myeloid leukemia (AML) and subsequently bladder cancer. On the two occasions, the eosinophilic fasciitis completely resolved upon successful treatment of the concomitant malignancy. The diagnosis of EF should trigger further evaluation for any associated hematological disorder, which, if adequately treated, can result in the resolution of EF.

Keywords: AML; Allogeneic hematopoietic stem cell transplant; Cord transplant; Eosinophilic fasciitis; MDS; Paraneoplastic.