Stem cell therapy for neonatal brain injury

Bobbi Fleiss; Pascale V Guillot; Luigi Titomanlio; Olivier Baud; Henrik Hagberg; Pierre Gressens

doi:10.1016/j.clp.2013.09.002

Stem cell therapy for neonatal brain injury

Clin Perinatol. 2014 Mar;41(1):133-48. doi: 10.1016/j.clp.2013.09.002. Epub 2013 Dec 12.

Authors

Bobbi Fleiss¹, Pascale V Guillot², Luigi Titomanlio³, Olivier Baud³, Henrik Hagberg⁴, Pierre Gressens⁵

Affiliations

¹ Inserm U676, Paris, 75019, France; University Paris Diderot, Sorbonne Paris Cité, UMRS 676, Paris, 75019, France; PremUP, Paris, 75019, France; Department of Perinatal Imaging and Health, Department of Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, London, SE1 7EH, UK.
² UCL Institute for Women's Health, University College London, London, WC1E 6HX, UK.
³ Inserm U676, Paris, 75019, France; University Paris Diderot, Sorbonne Paris Cité, UMRS 676, Paris, 75019, France; PremUP, Paris, 75019, France.
⁴ Department of Perinatal Imaging and Health, Department of Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, London, SE1 7EH, UK; Department of Clinical Sciences, Sahlgrenska Academy/East Hospital, 416 85 Gothenburg, Sweden; Department of Physiology and Neuroscience, Perinatal Center, Sahlgrenska Academy, Gothenburg University, 40530, Gothenburg, Sweden.
⁵ Inserm U676, Paris, 75019, France; University Paris Diderot, Sorbonne Paris Cité, UMRS 676, Paris, 75019, France; PremUP, Paris, 75019, France; Department of Perinatal Imaging and Health, Department of Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, London, SE1 7EH, UK. Electronic address: pierre.gressens@inserm.fr.

PMID: 24524451
DOI: 10.1016/j.clp.2013.09.002

Abstract

This article introduces the basic concepts of modeling neonatal brain injury and provides background information regarding each of the commonly used types of stem cells. It summarizes the findings of preclinical research testing the therapeutic potential of stem cells in animal models of neonatal brain injury, reports briefly on the status of clinical trials, and discusses the important ongoing issues that need to be addressed before stem cell therapy is used to repair the injured brain.

Keywords: Amniotic stem cells; Cord blood; Embryonic stem cells; Mesenchymal stem cells; Neural stem cells; Neuroprotection; Placental stem cells; Stem cell therapy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Amnion / cytology
Animals
Brain Injuries / therapy*
Combined Modality Therapy
Cord Blood Stem Cell Transplantation / methods
Disease Models, Animal
Embryonic Stem Cells / transplantation*
Female
Humans
Hypothermia, Induced
Hypoxia-Ischemia, Brain / therapy*
Infant, Newborn
Mesenchymal Stem Cell Transplantation / methods
Neural Stem Cells / transplantation*
Placenta / cytology
Pregnancy
Stem Cell Transplantation / methods*

Grants and funding

WT094823MA/Wellcome Trust/United Kingdom