Dissecting genomic diversity, one cell at a time

Nat Methods. 2014 Jan;11(1):19-21. doi: 10.1038/nmeth.2783.

Abstract

Emerging technologies are bringing single-cell genome sequencing into the mainstream; this field has already yielded insights into the genetic architecture and variability between cells that highlight the dynamic nature of the genome.

MeSH terms

  • Animals
  • Bacteria / genetics
  • Fertilization in Vitro / methods
  • Genetic Variation*
  • Genome
  • Genomics
  • Haplotypes
  • Humans
  • Mosaicism
  • Nucleic Acid Amplification Techniques*
  • Preimplantation Diagnosis
  • Sequence Analysis, DNA / methods*
  • Sequence Analysis, RNA / methods*
  • Single-Cell Analysis / methods*