Oncologic results of transoral laser microsurgery for squamous cell carcinoma of the posterior pharyngeal wall

Head Neck. 2015 Feb;37(2):156-61. doi: 10.1002/hed.23571. Epub 2014 Feb 12.

Abstract

Background: The purpose of this study was to evaluate oncologic outcomes of transoral laser microsurgery (TLM) in patients with cancer of the oropharyngeal and/or hypopharyngeal posterior wall.

Methods: Between August 1986 and December 2006, 25 patients (oropharyngeal n = 12; hypopharyngeal n = 13) were treated by primary CO2 laser microsurgery. Treatment was exclusively TLM with or without selective neck dissection in 12 cases (48%); TLM with adjuvant (chemo)radiotherapy was performed in 13 cases (52%).

Results: Data were analyzed by using the Kaplan-Meier method. The median follow-up was 41.6 months. The 5-year overall, recurrence-free, and disease-specific survival rates for stages I/II were 36,5%, 60,0%, and 87,5% and for stages III/IVa 41,2%, 36,4%, and 56,3%, respectively.

Conclusion: With respect to local control and survival, results are comparable to conventional surgery.

Keywords: carcinoma posterior pharyngeal wall; hypopharynx; oncologic and functional outcomes; oropharynx; transoral laser microsurgery.

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Squamous Cell / mortality
  • Carcinoma, Squamous Cell / pathology
  • Carcinoma, Squamous Cell / surgery*
  • Disease-Free Survival
  • Female
  • Humans
  • Hypopharyngeal Neoplasms / mortality
  • Hypopharyngeal Neoplasms / pathology
  • Hypopharyngeal Neoplasms / surgery*
  • Laser Therapy / methods*
  • Lasers, Gas
  • Male
  • Microsurgery / methods*
  • Middle Aged
  • Neck Dissection
  • Oropharyngeal Neoplasms / mortality
  • Oropharyngeal Neoplasms / pathology
  • Oropharyngeal Neoplasms / surgery*
  • Postoperative Complications
  • Salvage Therapy