A mild and selective Pd-mediated methodology for the synthesis of highly fluorescent 2-arylated tryptophans and tryptophan-containing peptides: a catalytic role for Pd(0) nanoparticles?

Chem Commun (Camb). 2014 Mar 21;50(23):3052-4. doi: 10.1039/c3cc48481e.

Abstract

A Pd-mediated direct C-H bond functionalisation of tryptophan has been developed, both as a single amino acid residue and within peptides. Important mechanistic insight into this process has been gained by characterising a Pd catalytically competent nanoparticle phase which evolves during the early stages of reaction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Fluorescent Dyes / chemical synthesis*
  • Fluorescent Dyes / chemistry
  • Palladium / chemistry*
  • Peptides / chemical synthesis*
  • Peptides / chemistry
  • Tryptophan / analogs & derivatives
  • Tryptophan / chemical synthesis*

Substances

  • Fluorescent Dyes
  • Peptides
  • Palladium
  • Tryptophan