Near infrared light-triggered drug generation and release from gold nanoparticle carriers for photodynamic therapy

Small. 2014 May 14;10(9):1799-804. doi: 10.1002/smll.201303329. Epub 2014 Feb 10.

Abstract

A photoprecursor Pc 227 is covalently bound onto gold nanoparticles (Au NPs) to produce the known photodynamic therapy (PDT) drug Pc 4 upon 660 nm photoirradiation. The photochemical formation of the photoproduct Pc 4 is identified by spectroscopy, chromatography, and mass spectrometry and its PDT efficacy is equal to Pc 4 when administered non-covalently by Au NPs, with the added benefit of improved covalent delivery and targeted NIR-triggered release from the covalent Pc 227-Au NP conjugate, while during transport the attached Pc 227 is quenched by the Au NP and PDT inactivated.

Keywords: caged drug; gold nanoparticle; photodynamic therapy; phototriggered release.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Drug Carriers / chemistry*
  • Gold / chemistry*
  • HeLa Cells
  • Humans
  • Indoles / pharmacology*
  • Infrared Rays*
  • Isoindoles
  • Metal Nanoparticles / chemistry*
  • Metal Nanoparticles / ultrastructure
  • Pharmaceutical Preparations
  • Photochemotherapy*
  • Spectrometry, Fluorescence
  • Spectrometry, Mass, Electrospray Ionization

Substances

  • Drug Carriers
  • Indoles
  • Isoindoles
  • Pharmaceutical Preparations
  • Gold
  • phthalocyanine