Fourier transform ion cyclotron resonance (FT ICR) mass spectrometry: Theory and simulations

Eugene N Nikolaev; Yury I Kostyukevich; Gleb N Vladimirov

doi:10.1002/mas.21422

Fourier transform ion cyclotron resonance (FT ICR) mass spectrometry: Theory and simulations

Mass Spectrom Rev. 2016 Mar-Apr;35(2):219-58. doi: 10.1002/mas.21422. Epub 2014 Feb 10.

Authors

Eugene N Nikolaev^{1

2

3

4}, Yury I Kostyukevich^{1

3}, Gleb N Vladimirov¹

Affiliations

¹ Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences, Leninskij pr. 38 k. 2, 119334, Moscow, Russia.
² Emanuel Institute for Biochemical Physics, Russian Academy of Sciences, Kosygina st. 4, 119334, Moscow, Russia.
³ Moscow Institute of Physics and Technology, 141700, Dolgoprudnyi, Moscow Region, Russia.
⁴ Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, ul. Pogodinskaya 10, 119121, Moscow, Russia.

PMID: 24515872
DOI: 10.1002/mas.21422

Abstract

Fourier transform ion cyclotron resonance (FT ICR) mass spectrometer offers highest resolving power and mass accuracy among all types of mass spectrometers. Its unique analytical characteristics made FT ICR important tool for proteomics, metabolomics, petroleomics, and investigation of complex mixtures. Signal acquisition in FT ICR MS takes long time (up to minutes). During this time ion-ion interaction considerably affects ion motion and result in decreasing of the resolving power. Understanding of those effects required complicated theory and supercomputer simulations but culminated in the invention of the ion trap with dynamic harmonization which demonstrated the highest resolving power ever achieved. In this review we summarize latest achievements in theory and simulation of FT ICR mass spectrometers.

Keywords: FT ICR; MS; non-neutral plasma; simulation.

Publication types

Research Support, Non-U.S. Gov't
Review