Optical coherence correlation spectroscopy (OCCS)

Opt Express. 2014 Jan 13;22(1):782-802. doi: 10.1364/OE.22.000782.

Abstract

We present a new method called optical coherence correlation spectroscopy (OCCS) using nanoparticles as reporters of kinetic processes at the single particle level. OCCS is a spectral interferometry based method, thus giving simultaneous access to several sampling volumes along the optical axis. Based on an auto-correlation analysis, we extract the diffusion coefficients and concentrations of nanoparticles over a large concentration range. The cross-correlation analysis between adjacent sampling volumes allows to measure flow parameters. This shows the potential of OCCS for spatially resolved diffusion and flow measurements.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Diffusion
  • Molecular Imaging / methods*
  • Nanoparticles / chemistry*
  • Nanoparticles / ultrastructure*
  • Spectrum Analysis / methods*
  • Tomography, Optical Coherence / methods*