Differential diagnosis of psychiatric symptoms after deep brain stimulation for movement disorders

Neuromodulation. 2014 Oct;17(7):629-36; discussion 636. doi: 10.1111/ner.12153. Epub 2014 Feb 11.

Abstract

Objectives: The presence of a deep brain stimulator (DBS) in a patient with a movement disorder who develops psychiatric symptoms poses unique diagnostic and therapeutic challenges for the treating clinician. Few sources discuss approaches to diagnosing and treating these symptoms.

Materials and methods: The authors review the literature on psychiatric complications in DBS for movement disorders and propose a heuristic for categorizing symptoms according to their temporal relationship with the DBS implantation process.

Results: Psychiatric symptoms after DBS can be categorized as preimplantation, intra-operative/perioperative, stimulation related, device malfunction, medication related, and chronic stimulation related/long term. Once determined, the specific etiology of a symptom guides the practitioner in treatment.

Conclusions: A structured approach to psychiatric symptoms in DBS patients allows practitioners to effectively diagnose and treat them when they arise.

Keywords: Deep brain stimulation; depression; movement disorders.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Databases, Bibliographic / statistics & numerical data
  • Deep Brain Stimulation / adverse effects*
  • Diagnosis, Differential*
  • Humans
  • Mental Disorders / diagnosis*
  • Mental Disorders / etiology*
  • Movement Disorders / therapy*