Hereditary spastic paraplegia type 5: a potentially treatable disorder of cholesterol metabolism

J Neurol. 2014 Mar;261(3):617-9. doi: 10.1007/s00415-014-7253-7. Epub 2014 Feb 8.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adult
  • Anticholesteremic Agents / administration & dosage
  • Anticholesteremic Agents / pharmacology*
  • Cytochrome P450 Family 7
  • Female
  • Humans
  • Hydroxycholesterols / blood*
  • Male
  • Mutation / genetics
  • Simvastatin / administration & dosage
  • Simvastatin / pharmacology*
  • Spastic Paraplegia, Hereditary / blood
  • Spastic Paraplegia, Hereditary / diagnosis*
  • Spastic Paraplegia, Hereditary / drug therapy*
  • Spastic Paraplegia, Hereditary / genetics
  • Steroid Hydroxylases / genetics
  • Treatment Outcome
  • Young Adult

Substances

  • Anticholesteremic Agents
  • Hydroxycholesterols
  • 27-hydroxycholesterol
  • Simvastatin
  • Steroid Hydroxylases
  • Cytochrome P450 Family 7
  • CYP7B1 protein, human