Abstract
It is accepted widely that fast-twitch muscle fibers are preferentially impacted in aging muscle, yet we hypothesize that this is not valid when aging muscle atrophy becomes severe. In this review, we summarize the evidence of fiber type-specific effect in aging muscle and the potential confounding roles of fibers coexpressing multiple myosin heavy-chain isoforms and their histochemical identification.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adenosine Triphosphatases
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Aging / pathology
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Aging / physiology*
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Animals
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Histocytochemistry
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Humans
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Muscle Fibers, Fast-Twitch / chemistry
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Muscle Fibers, Fast-Twitch / classification*
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Muscle Fibers, Fast-Twitch / physiology*
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Muscle Fibers, Slow-Twitch / chemistry
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Muscle Fibers, Slow-Twitch / classification*
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Muscle Fibers, Slow-Twitch / physiology*
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Muscular Atrophy / physiopathology*
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Myosin Heavy Chains / analysis
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Protein Isoforms / analysis
Substances
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Protein Isoforms
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Adenosine Triphosphatases
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Myosin Heavy Chains