The emerging biomolecular role of vitamin D in skeletal muscle

Exerc Sport Sci Rev. 2014 Apr;42(2):76-81. doi: 10.1249/JES.0000000000000013.

Abstract

In this review, we summarize current evidence for a direct effect of vitamin D on skeletal muscle. A number of studies identify the receptor for 1,25-dihydroxyvitamin-D3 (vitamin D receptor (VDR)) and the enzyme CYP27B1 (1-α-hydroxylase) in muscle. We hypothesize that vitamin D acts on myocytes via the VDR, and we examine proposed effects on myocyte proliferation, differentiation, growth, and inflammation.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • 25-Hydroxyvitamin D3 1-alpha-Hydroxylase / metabolism
  • Animals
  • Cell Differentiation
  • Cell Proliferation
  • Humans
  • Muscle Cells / cytology
  • Muscle Contraction
  • Muscle, Skeletal / cytology
  • Muscle, Skeletal / metabolism
  • Muscle, Skeletal / physiology*
  • Receptors, Calcitriol / isolation & purification
  • Receptors, Calcitriol / metabolism*
  • Vitamin D / metabolism*

Substances

  • Receptors, Calcitriol
  • Vitamin D
  • 25-Hydroxyvitamin D3 1-alpha-Hydroxylase