Diffuse X-ray scattering to model protein motions

Michael E Wall; Paul D Adams; James S Fraser; Nicholas K Sauter

doi:10.1016/j.str.2014.01.002

Diffuse X-ray scattering to model protein motions

Structure. 2014 Feb 4;22(2):182-4. doi: 10.1016/j.str.2014.01.002.

Authors

Michael E Wall¹, Paul D Adams², James S Fraser³, Nicholas K Sauter⁴

Affiliations

¹ Computer, Computational, and Statistical Sciences Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA. Electronic address: mewall@lanl.gov.
² Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA.
³ Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.
⁴ Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

Abstract

Problems in biology increasingly need models of protein flexibility to understand and control protein function. At the same time, as they improve, crystallographic methods are marching closer to the limits of what can be learned from Bragg data in isolation. It is thus inevitable that mainstream protein crystallography will turn to diffuse scattering to model protein motions and improve crystallographic models. The time is ripe to make it happen.

Publication types

Congress
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

California
Crystallography, X-Ray / methods
Molecular Dynamics Simulation
Motion
Protein Conformation
Proteins / chemistry*
Scattering, Radiation
X-Rays

Substances

Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding