Triterpenoid saponins from Polycarpaea corymbosa Lamk. var. eriantha Hochst

Phytochemistry. 2014 Apr:100:150-5. doi: 10.1016/j.phytochem.2013.12.005. Epub 2014 Feb 4.

Abstract

Four triterpenoid saponins (1-4) were isolated from Polycarpaea corymbosa Lamk. var. eriantha Hochst along with the known apoanagallosaponin IV (5). Their structures were elucidated by spectroscopic data analysis. Among the compounds 1, 3-5 which were evaluated for their cytotoxicity against three tumor cell lines (SW480, DU145 and EMT6), compound 1 exhibited cytotoxicity with IC50 values ranging from 4.61 to 22.61 μM, which was greater than that of etoposide. Compound 2 was tested only against SW480 and a cardiomyoblast cell line (H9c2), and was inactive.

Keywords: Caryophyllaceae; Cytotoxicity; NMR; Polycarpaea corymbosa; Triterpene saponins.

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Caryophyllaceae / chemistry*
  • Cell Line, Tumor
  • Humans
  • Inhibitory Concentration 50
  • Saponins / chemistry*
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology*

Substances

  • Antineoplastic Agents, Phytogenic
  • Saponins
  • Triterpenes