Hypothalamic tanycytes: gatekeepers to metabolic control

Yuanqing Gao; Matthias H Tschöp; Serge Luquet

doi:10.1016/j.cmet.2014.01.008

Hypothalamic tanycytes: gatekeepers to metabolic control

Cell Metab. 2014 Feb 4;19(2):173-5. doi: 10.1016/j.cmet.2014.01.008.

Authors

Yuanqing Gao¹, Matthias H Tschöp², Serge Luquet³

Affiliations

¹ Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg & Division of Metabolic Diseases, Technische Universität München, Munich, Germany.
² Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg & Division of Metabolic Diseases, Technische Universität München, Munich, Germany. Electronic address: matthias.tschoep@helmholtz-muenchen.de.
³ Univ Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative (BFA) UMR 8251 CNRS, F-75205, Paris, France.

PMID: 24506860
DOI: 10.1016/j.cmet.2014.01.008

Abstract

How circulating signals of hunger and satiety enter the brain to reach neurons that govern energy balance has long remained a matter of controversy and speculation. Balland et al. (2014) now elucidate molecular mechanisms by which a highly specialized hypothalamic glial cell regulates transport of leptin across the blood-brain barrier.

Publication types

Comment

MeSH terms

Animals
Brain / metabolism*
Ependymoglial Cells / metabolism*
Hypothalamus / metabolism*
Leptin / metabolism*
Male

Substances

Leptin