Introducing MINA--The Molecularly Imprinted Nanoparticle Assay

Small. 2014 Mar 26;10(6):1086-9. doi: 10.1002/smll.201301996. Epub 2014 Feb 6.

Abstract

A new ELISA- (enzyme-linked immunosorbent assay)-like assay is demonstrated in which no elements of biological origin are used for molecular recognition or signaling. Composite imprinted nanoparticles that contain a catalytic core and which are synthesized by using a solid-phase approach can simultaneously act as recognition/signaling elements, and be used with minimal modifications to standard assay protocols. This assay provides a new route towards replacement of unstable biomolecules in immunoassays.

Keywords: core-shell materials; molecular imprinting; peroxidases; solid-phase synthesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Calibration
  • Ferric Compounds / chemistry
  • Immunoassay / methods*
  • Kinetics
  • Microscopy, Atomic Force
  • Molecular Imprinting / methods*
  • Nanoparticles / chemistry*
  • Peroxidase / metabolism
  • Solid-Phase Synthesis Techniques
  • Vancomycin / pharmacology

Substances

  • Ferric Compounds
  • ferric oxide
  • Vancomycin
  • Peroxidase