Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor

Chem Commun (Camb). 2014 Mar 21;50(23):3027-9. doi: 10.1039/c3cc00173c.

Abstract

The RNA motifs that bind guanidinylated kanamycin A (G Kan A) and guanidinylated neomycin B (G Neo B) were identified via two-dimensional combinatorial screening (2DCS). The results of these studies enabled the "bottom-up" design of a small molecule inhibitor of oncogenic microRNA-10b.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / metabolism*
  • Base Sequence
  • Combinatorial Chemistry Techniques
  • Drug Design*
  • Framycetin / metabolism*
  • Humans
  • Kanamycin / metabolism*
  • MicroRNAs / antagonists & inhibitors*
  • MicroRNAs / chemistry
  • MicroRNAs / metabolism
  • Molecular Sequence Data
  • Small Molecule Libraries / chemistry*
  • Small Molecule Libraries / pharmacology*

Substances

  • Anti-Bacterial Agents
  • MIRN10 microRNA, human
  • MicroRNAs
  • Small Molecule Libraries
  • Framycetin
  • Kanamycin