Balloon-expandable stents are currently used with satisfactory results in percutaneous coronary interventions. Unfortunately, in challenging anatomical patterns such as high thrombotic burden lesions, outcomes are often impaired. The STENTYS® stent (STENTYS, Paris, France), with its self-expandable capacity and peculiar Z-shape design, has been recently introduced in the clinical arena as an alternative to balloon-expandable stents for challenging lesion subsets. This article provides an overview of clinical trials, completed and currently on-going, on this self-apposing technology.