Abstract
Eight new limonoids (1-8) and one new phenol glycoside (9), along with six known compounds, were isolated from the leaves of Azaridachta indica. The structures of 1-9 were elucidated on the basis of spectroscopic data analysis. Compounds isolated were assayed for their cytotoxicity against different cancer cell lines. Moreover, their ability to interact with the molecular chaperone Hsp90, affecting its biological activity, was tested.
MeSH terms
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / isolation & purification*
-
Antineoplastic Agents, Phytogenic / pharmacology*
-
Azadirachta / chemistry*
-
Drug Screening Assays, Antitumor
-
HSP90 Heat-Shock Proteins / metabolism
-
HeLa Cells
-
Humans
-
Limonins / chemistry
-
Limonins / isolation & purification*
-
Limonins / pharmacology*
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Plant Leaves / chemistry
-
Venezuela
Substances
-
Antineoplastic Agents, Phytogenic
-
HSP90 Heat-Shock Proteins
-
Limonins