Biomarkers as outcome predictors in subarachnoid hemorrhage--a systematic review

Biomarkers. 2014 Mar;19(2):95-108. doi: 10.3109/1354750X.2014.881418. Epub 2014 Feb 5.

Abstract

Context: Subarachnoid hemorrhage (SAH) has a high fatality rate and many suffer from delayed neurological deficits. Biomarkers may aid in the identification of high-risk patients, guide treatment/management and improve outcome.

Objective: The aim of this review was to summarize biomarkers of SAH associated with outcome.

Methods: An electronic database query was completed, including an additional review of reference lists to include all potential human studies.

Results: A total of 298 articles were identified; 112 were reviewed; 55 studies were included.

Conclusion: This review details biomarkers of SAH that correlate with outcome. It provides the basis for research investigating their possible translation into the management of SAH patients.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Animals
  • Biomarkers / blood
  • Humans
  • Prognosis
  • Subarachnoid Hemorrhage / blood*
  • Subarachnoid Hemorrhage / diagnosis
  • Subarachnoid Hemorrhage / therapy
  • Treatment Outcome

Substances

  • Biomarkers