Synthetic aminomethylnaphthoquinones inhibit the in vitro replication of bovine herpesvirus 5

Arch Virol. 2014 Jul;159(7):1827-33. doi: 10.1007/s00705-014-1989-3. Epub 2014 Feb 4.

Abstract

Bovine herpesvirus type 5 (BoHV-5) is an etiologic agent of meningoencephalitis in cattle. The aim of this study was to evaluate the antiviral potential of a series of synthetic Mannich bases derived from lawsone and to investigate at which stage of the BoHV-5 replicative cycle the compounds might be acting. The most potent and selective inhibitor exhibited CC50 and EC50 values of 1867 μM ± 8.3 and 3.8 μM ± 1.2, respectively (ACV: 989 μM ± 2 and 166 μM ± 2, respectively).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acyclovir / pharmacology
  • Animals
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Cell Line
  • Dogs
  • Dose-Response Relationship, Drug
  • Herpesvirus 5, Bovine / drug effects*
  • Herpesvirus 5, Bovine / physiology
  • Molecular Structure
  • Naphthoquinones / chemistry
  • Naphthoquinones / pharmacology*
  • Viral Plaque Assay
  • Virus Replication / drug effects*

Substances

  • Antiviral Agents
  • Naphthoquinones
  • Acyclovir