Abstract
New meroterpenoids, nakijiquinone S (1) and nakijinol C (2), have been isolated from an Okinawan marine sponge of the family Spongiidae. The gross structures and relative stereochemistries of 1 and 2 were elucidated on the basis of their spectral data. Nakijiquinone S (1) and nakijinol C (2) were new meroterpenoids consisting of a clerodane-type decalin ring connected to a 2-butoxy-5-hydroxy-benzoquinone unit or methyl 2,3,4-trihydroxybenzoate unit through a methylene, respectively. Nakijiquinone S (1) and nakijinol C (2) showed antimicrobial activities against several bacteria and fungi.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Infective Agents / chemistry*
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / pharmacology*
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Bacteria / drug effects
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Bacterial Infections / drug therapy
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Benzoquinones / chemistry*
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Benzoquinones / isolation & purification
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Benzoquinones / pharmacology*
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Fungi / drug effects
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Models, Molecular
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Mycoses / drug therapy
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Porifera / chemistry*
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Pyrogallol / analogs & derivatives*
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Pyrogallol / chemistry
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Pyrogallol / isolation & purification
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Pyrogallol / pharmacology
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Sesquiterpenes / chemistry*
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology*
Substances
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Anti-Infective Agents
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Benzoquinones
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Sesquiterpenes
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nakijinol C
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nakijiquinone S
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Pyrogallol