Uptake and biological effects of synthetic glucocorticoids in common carp (Cyprinus carpio)

Mar Pollut Bull. 2014 Aug 30;85(2):370-5. doi: 10.1016/j.marpolbul.2014.01.042. Epub 2014 Jan 31.

Abstract

Uptake and biological effects of synthetic glucocorticoids (GCs) were analyzed using common carp (Cyprinus carpio). Fish were exposed to clobetasol propionate (CP) or clobetasone butyrate (CB) individually or in mixture at 1 μg L(-1) for 21 days. Bioconcentration factor (BCF) of CB was calculated as 100, and BCF of CP was less than 16. No effects were found in fish erythrocyte and leukocyte numbers and serum glucose levels after exposure to the selected GCs. On the other hand, serum concentrations of free amino acids significantly increased in GC-exposed groups. Thus, exposures to synthetic GCs at relatively low concentrations seemed to cause enhancement of protein degradation and subsequent increase of serum free amino acids without a corresponding increase in serum glucose levels, an effect which might be related to partial induction of gluconeogenesis by GC.

Keywords: Bioconcentration factor; Blood cell composition; Common carp; Free amino acid; Glucocorticoid; Glucose.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / blood
  • Animals
  • Blood Glucose / drug effects
  • Carps / metabolism*
  • Carps / physiology
  • Clobetasol / analogs & derivatives*
  • Clobetasol / pharmacokinetics*
  • Clobetasol / pharmacology
  • Erythrocyte Count
  • Glucocorticoids / pharmacokinetics*
  • Glucocorticoids / pharmacology
  • Leukocyte Count
  • Proteolysis / drug effects

Substances

  • Amino Acids
  • Blood Glucose
  • Glucocorticoids
  • clobetasone butyrate
  • Clobetasol