Associations between polymorphisms of LSAMP gene and schizophrenia

Kati Koido; Sven Janno; Tanel Traks; Madis Parksepp; Ülle Ljubajev; Peeter Veiksaar; Anne Must; Jakov Shlik; Veiko Vasar; Eero Vasar

doi:10.1016/j.psychres.2014.01.016

Associations between polymorphisms of LSAMP gene and schizophrenia

Psychiatry Res. 2014 Mar 30;215(3):797-8. doi: 10.1016/j.psychres.2014.01.016. Epub 2014 Jan 21.

Authors

Affiliations

¹ Institute of Biomedicine and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia; Centre of Excellence for Translational Medicine, University of Tartu, Tartu, Estonia. Electronic address: kati.koido@ut.ee.
² Department of Psychiatry, University of Tartu, Tartu, Estonia.
³ Institute of Biomedicine and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia; Centre of Excellence for Translational Medicine, University of Tartu, Tartu, Estonia.
⁴ Department of Psychiatry, University of Ottawa, Ottawa, Ontario, Canada.

PMID: 24491686
DOI: 10.1016/j.psychres.2014.01.016

Abstract

The purpose of this study was to explore relationships between single-nucleotide polymorphisms (SNPs) in the limbic system-associated membrane protein (LSAMP) gene and schizophrenia. Twenty-two SNPs were analysed in 127 unrelated schizophrenic patients and in 171 healthy controls. The results showed significant allelic and haplotypic associations between LSAMP gene and schizophrenia.

Keywords: Case-control genetic association study; Cell adhesion molecule; SNP.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Alleles
Case-Control Studies
Cell Adhesion Molecules, Neuronal / genetics*
Estonia
Female
GPI-Linked Proteins / genetics
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide*
Schizophrenia / genetics*
Schizophrenic Psychology

Substances

Cell Adhesion Molecules, Neuronal
GPI-Linked Proteins
limbic system-associated membrane protein