Intra-tumor distribution of metallofullerene using micro-particle induced X-ray emission (PIXE)

Appl Radiat Isot. 2014 Jun:88:114-7. doi: 10.1016/j.apradiso.2013.12.037. Epub 2014 Jan 8.

Abstract

To clarify the intra tumor distribution of gadlinium containing fullerene (Gd@C82), micro particle induced X-ray emission (Micro-PIXE) analysis were performed. The tumor bearing BALB/c mice were injected Gd@C82 and subcutaneous tumors were taken from 48h after the intravenous injection. Using the Micro-PIXE method, we could visualize Gd intra tumor distribution. Therefore our results indicate the possibility that Micro-PIXE is useful technique for imaging the bioditribution of Gd, and Gd@C82 is potentially useful Gd carrier for NCT.

Keywords: Biodistribution; Fullerene; Gd@C(82); Metallofullerene; Micro-Particle Induced X-ray Emission (Micro-PIXE); Neutron Capture Therapy (NCT).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Colonic Neoplasms / chemistry*
  • Colonic Neoplasms / pathology*
  • Fullerenes / chemistry*
  • Fullerenes / therapeutic use
  • Gadolinium / chemistry*
  • Gadolinium / therapeutic use
  • Mice
  • Mice, Inbred BALB C
  • Microspheres
  • Spectrometry, X-Ray Emission / methods*

Substances

  • Fullerenes
  • Gadolinium