Recent advances in Phytosterol Oxidation Products

Abstract

Phytosterols and their oxidation products have become increasingly investigated in recent years with respect to their roles in diet and nutrition. We present a comprehensive review of recent literature on Phytosterol Oxidation Products (POP) identifying critical areas for future investigation. It is evident that POP are formed on food storage/preparation; are absorbed and found in human serum; do not directly affect cholesterol absorption; have evidence of atherogenicity and inflammation; have distinct levels of cytotoxicity; are implicated with high levels of oxidative stress, glutathione depletion, mitochondrial dysfunction and elevated caspase activity.

Keywords: Atherosclerosis; Campesterol; Cholesterol absorption; Dihydrobrassicasterol; Oxidative stress; Phytosterol Oxidation Products; Phytosterols; Stigmasterol; Toxicity; β-Sitosterol.