XRCC1 Arg399Gln polymorphism confers risk of breast cancer in American population: a meta-analysis of 10846 cases and 11723 controls

Tao Bu; Li Liu; Yong Sun; Li Zhao; Yang Peng; Shudong Zhou; Lixia Li; Sidong Chen; Yanhui Gao

doi:10.1371/journal.pone.0086086

XRCC1 Arg399Gln polymorphism confers risk of breast cancer in American population: a meta-analysis of 10846 cases and 11723 controls

PLoS One. 2014 Jan 28;9(1):e86086. doi: 10.1371/journal.pone.0086086. eCollection 2014.

Authors

Tao Bu¹, Li Liu², Yong Sun³, Li Zhao², Yang Peng², Shudong Zhou², Lixia Li², Sidong Chen², Yanhui Gao²

Affiliations

¹ Department of Epidemiology and Biostatistics, School of Public Health and Guangdong Key Lab of Molecular Epidemiology, Guangdong Pharmaceutical University, Guangzhou, China ; Department of Prevention and Health Care, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
² Department of Epidemiology and Biostatistics, School of Public Health and Guangdong Key Lab of Molecular Epidemiology, Guangdong Pharmaceutical University, Guangzhou, China.
³ Department of Prevention and Health Care, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Abstract

Background: In the X-ray repair cross-complementing group 1 (XRCC1) gene, a polymorphism, Arg399Gln (rs25487), has been shown to change neoconservative amino acid and thus result in alternation of DNA repair capacity. Numerous studies have investigated the association between Arg399Gln and breast cancer risk in the American population, but yielding inconsistent results. This study aimed to clarify the role of this polymorphism in susceptibility to breast cancer.

Methods: Literatures were searched in multiple databases including PubMed, Springer Link, Ovid, EBSCO and ScienceDirect databases up to April 2013. A comprehensive meta-analysis was conducted to estimate the overall odds ratio (OR), by integrating data from 18 case control studies of 10846 cases and 11723 controls in the American population.

Results: Overall, significant association was observed between the Arg399Gln polymorphism and breast cancer risk under the random-effects model (OR for dominant model = 1.12, 95% CI: 1.02-1.24, P heterogeneity = 0.003; OR for additive model = 1.07, 95% CI: 1.01-1.14, P heterogeneity = 0.017). Further sensitivity analysis supported the robust stability of this current result by showing similar ORs before and after removal of a single study.

Conclusions: This meta-analysis suggests that the XRCC1 Arg399Gln polymorphism may significantly contribute to susceptibility of breast cancer in the American population.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Breast Neoplasms / epidemiology
Breast Neoplasms / genetics*
Case-Control Studies
DNA-Binding Proteins / genetics*
Female
Genetic Predisposition to Disease / genetics
Humans
Polymorphism, Genetic / genetics*
X-ray Repair Cross Complementing Protein 1

Substances

DNA-Binding Proteins
X-ray Repair Cross Complementing Protein 1
XRCC1 protein, human

Grants and funding

This work was supported by Medical Scientific Research Foundation of Guangdong Province B2012176 and Foundation for Distinguished Young Talents in Higher Education of Guangdong 2012LYM_0082 to Li Liu. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.