Abstract
A new bacterial nitroreductase has been identified and used as a biocatalyst for the controllable reduction of a variety of nitroarenes with an electron-withdrawing group to the corresponding N-arylhydroxylamines under mild reaction conditions with excellent selectivity (>99%). This method therefore represents a green and efficient method for the synthesis of arylhydroxylamines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacillus / metabolism
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Bacterial Proteins / chemistry*
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Bacterial Proteins / metabolism
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Biocatalysis
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Green Chemistry Technology
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Hydroxylamines / chemical synthesis*
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Nitro Compounds / chemistry*
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Nitroreductases / chemistry*
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Nitroreductases / metabolism
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Oxidation-Reduction
Substances
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Bacterial Proteins
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Hydroxylamines
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Nitro Compounds
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Nitroreductases