Highly selective and controllable synthesis of arylhydroxylamines by the reduction of nitroarenes with an electron-withdrawing group using a new nitroreductase BaNTR1

Chem Commun (Camb). 2014 Mar 18;50(22):2861-4. doi: 10.1039/c3cc48590k. Epub 2014 Feb 3.

Abstract

A new bacterial nitroreductase has been identified and used as a biocatalyst for the controllable reduction of a variety of nitroarenes with an electron-withdrawing group to the corresponding N-arylhydroxylamines under mild reaction conditions with excellent selectivity (>99%). This method therefore represents a green and efficient method for the synthesis of arylhydroxylamines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacillus / metabolism
  • Bacterial Proteins / chemistry*
  • Bacterial Proteins / metabolism
  • Biocatalysis
  • Green Chemistry Technology
  • Hydroxylamines / chemical synthesis*
  • Nitro Compounds / chemistry*
  • Nitroreductases / chemistry*
  • Nitroreductases / metabolism
  • Oxidation-Reduction

Substances

  • Bacterial Proteins
  • Hydroxylamines
  • Nitro Compounds
  • Nitroreductases