Abstract
Biological activities of different varieties of tomato seed extracts were evaluated to verify the potential antioxidant and/or antiproliferative activity of the bioactive metabolites present in them. Findings demonstrated that among all the varieties investigated (San Marzano Rosso, San Marzano Giallo, Corbarino, Black Tomato and San Marzano/Black Tomato hybrid) San Marzano Rosso seed extract exhibited the highest free radical-scavenging activity with 68% of 2,2-Diphenyl-1-picrylhydrazyl radical inhibition, and the best cytotoxic activity evaluated by using the brine shrimp test (LD50: 23,198 ppm) and 3-(4,5-dimethylthiazol-2-yl)-2,5-phenyl-2H-tetrazolium bromide assay on A375 cell line (IC50: 137.7 μg/mL).
Keywords:
Tomato; antioxidant activity; cytotoxicity; seed extracts.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Antioxidants / chemistry
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Antioxidants / isolation & purification*
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Antioxidants / pharmacology*
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Artemia / drug effects
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Biphenyl Compounds / pharmacology
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / isolation & purification*
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Free Radical Scavengers / pharmacology*
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Humans
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Italy
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Phenols / analysis
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Phytotherapy
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Picrates / pharmacology
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification*
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Plant Extracts / pharmacology*
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Seeds / chemistry
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Solanum lycopersicum / chemistry*
Substances
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Antineoplastic Agents, Phytogenic
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Antioxidants
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Biphenyl Compounds
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Free Radical Scavengers
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Phenols
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Picrates
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Plant Extracts
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1,1-diphenyl-2-picrylhydrazyl