Synthesis of multi-substituted pyrroles using enamides and alkynes catalyzed by Pd(OAc)2 with molecular oxygen as an oxidant

Chem Commun (Camb). 2014 Mar 14;50(21):2784-6. doi: 10.1039/c3cc49683j.

Abstract

A cyclization reaction between enamides and alkynes catalyzed by palladium(II) acetate is described. In this method, the molecular oxygen serves as an efficient oxidant for the Pd(II)/Pd(0) catalytic cycle. The simple reaction conditions permit this methodology to be used as a general tool for the preparation of multi-substituted pyrroles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetates / chemistry*
  • Alkynes / chemistry*
  • Amides / chemistry*
  • Catalysis
  • Cyclization
  • Oxidants / chemistry
  • Oxygen / chemistry
  • Palladium / chemistry*
  • Pyrroles / chemical synthesis*

Substances

  • Acetates
  • Alkynes
  • Amides
  • Oxidants
  • Pyrroles
  • Palladium
  • Oxygen