Fully interlocking: a story of teamwork among breast epithelial cells

Dev Cell. 2014 Jan 27;28(2):114-5. doi: 10.1016/j.devcel.2014.01.011.

Abstract

In this issue of Developmental Cell, Forster et al. (2014) show that the basal myoepithelial cell layer directs the final maturation of the adjacent luminal cell sheet during pregnancy. Do all mammary epithelial cells both give and take instructions from others to create the milk production machinery?

Publication types

  • Comment

MeSH terms

  • Adult Stem Cells / metabolism*
  • Animals
  • Epithelial Cells / metabolism*
  • Female
  • Humans
  • Lactation*
  • Neuregulin-1 / metabolism*
  • Phosphoproteins / metabolism*
  • Pregnancy
  • Trans-Activators / metabolism*

Substances

  • Neuregulin-1
  • Nrg1 protein, mouse
  • Phosphoproteins
  • Trans-Activators
  • Trp63 protein, mouse