Neutrophil gelatinase-associated lipocalin after off pump versus on pump coronary artery surgery

Biomarkers. 2014 Feb;19(1):22-8. doi: 10.3109/1354750X.2013.863974.

Abstract

Context: Cardiac surgery.

Objective: To compare plasma and urinary neutrophil gelatinase-associated lipocalin (P-/U-NGAL) in on-pump (n = 43) versus off-pump (n = 40) surgery.

Materials and methods: We obtained perioperative P-/U-NGAL and outcome data.

Results: P-/U-NGAL increased after surgery. P-NGAL was higher post-surgery in on pump patients (139 versus 67 µg L(-1); p < 0.001), but not at 24 h. There were no differences in U-NGAL. Correlation between P-/U-NGAL and plasma creatinine was weak.

Discussion: P-NGAL acts like a neutrophil activation biomarker and U-NGAL like a tubular injury marker.

Conclusion: On-pump patients had greater neutrophil activation. On- versus off-pump surgery had similar impact on tubular cells.

Publication types

  • Comparative Study
  • Observational Study

MeSH terms

  • Acute Kidney Injury / blood
  • Acute Kidney Injury / etiology
  • Acute Kidney Injury / urine
  • Acute-Phase Proteins / urine
  • Aged
  • Biomarkers / blood
  • Biomarkers / urine
  • Cardiopulmonary Bypass / adverse effects
  • Coronary Artery Disease / blood*
  • Coronary Artery Disease / surgery
  • Coronary Artery Disease / urine
  • Creatinine / blood
  • Female
  • Humans
  • Kidney Transplantation
  • Lipocalin-2
  • Lipocalins / blood*
  • Lipocalins / urine
  • Male
  • Middle Aged
  • Postoperative Complications / blood*
  • Postoperative Complications / urine
  • Prospective Studies
  • Proto-Oncogene Proteins / blood*
  • Proto-Oncogene Proteins / urine
  • Treatment Outcome

Substances

  • Acute-Phase Proteins
  • Biomarkers
  • LCN2 protein, human
  • Lipocalin-2
  • Lipocalins
  • Proto-Oncogene Proteins
  • Creatinine