The world population with an increase of 75% will be 10 billion by 2050. Current contraception methods have difficulties, and there is no safe and ideal way of contraception. Contraception, which based on immunocontraception stimulation, is a modern method presentation. This study is going to review and examine the response of anti-sperm anti-body in serum and uterus secretions, and resultant infertility induction rate. Despite of current different contradictions in the field of mature sperm protein capability in infertility induction, the results of this study showed that, immunocontraception stimulation is the best way of infertility induction. Antibody response induction is wholly depends on the type of immunogenic element and its method of presentation. Compared with other different methods of presentation, the intramuscular presentation method was efficient than mucous presentation methods. Perhaps the inefficiency of mucous methods is due to the largeness of mature sperm antigen and mucous cells inability in presentation of this antigen to immune system in mucous presentation methods. More studies should be done in future.