Abstract
The work presented here reports the use of long lifetime (>1 μs) BSA Au clusters as a cellular/tissue, time gated, intensity imaging probe. By collecting the emission signal 50 ns post excitation, one can off-gate the intense auto-fluorescence background, thereby greatly enhancing the clarity/specificity in fluorescence imaging.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Cattle
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Cell Line, Tumor
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Fluorescent Dyes / chemistry
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Fluorescent Dyes / metabolism*
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Gold / chemistry*
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Mice
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Microscopy, Fluorescence
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Nanostructures / chemistry*
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Serum Albumin, Bovine / chemistry*
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Serum Albumin, Bovine / metabolism
Substances
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Fluorescent Dyes
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Serum Albumin, Bovine
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Gold