Long lived BSA Au clusters as a time gated intensity imaging probe

Nanoscale. 2014 Mar 7;6(5):2594-7. doi: 10.1039/c3nr05692a. Epub 2014 Jan 27.

Abstract

The work presented here reports the use of long lifetime (>1 μs) BSA Au clusters as a cellular/tissue, time gated, intensity imaging probe. By collecting the emission signal 50 ns post excitation, one can off-gate the intense auto-fluorescence background, thereby greatly enhancing the clarity/specificity in fluorescence imaging.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cattle
  • Cell Line, Tumor
  • Fluorescent Dyes / chemistry
  • Fluorescent Dyes / metabolism*
  • Gold / chemistry*
  • Mice
  • Microscopy, Fluorescence
  • Nanostructures / chemistry*
  • Serum Albumin, Bovine / chemistry*
  • Serum Albumin, Bovine / metabolism

Substances

  • Fluorescent Dyes
  • Serum Albumin, Bovine
  • Gold