Purpose: To explore the expression of CytC in the labial glands of patients with primary Sjogren's syndrome(pSS).
Methods: Thirty-five cases with pSS and 15 controls were collected. Immunohistochemistry and RT-PCR were used to examine CytC protein and mRNA in labial glands of 2 groups. The integral optical density were measured and the data was analyzed by Mann-Whitney test with SPSS14.0 software package. The correlation between the clinical manifestations and the expression of CytC were calculated by Spearman's analysis.
Results: The expression of CytC protein and mRNA in pSS were positively correlated with the disease course and significantly higher than those in control group (P<0.05). There was a positive correlation between the lymphocyte focus score and the expression of CytC, but no correlation with the other clinical parameters.
Conclusions: The expression of CytC in pSS is increased,which is related to the disease course and the lymphocyte focus score. Supported by Science and Technology Research Project of Liaoning Province (2011225020) and College Scientific Research Foundation for Youth in 2013 (K101593-13-39).