Urinary excretion of arsenicals following daily intake of various seafoods during a two weeks intervention

M Molin; S M Ulven; L Dahl; W Goessler; D Fliegel; M Holck; J J Sloth; A Oshaug; J Alexander; H M Meltzer; T A Ydersbond

doi:10.1016/j.fct.2014.01.030

Urinary excretion of arsenicals following daily intake of various seafoods during a two weeks intervention

Food Chem Toxicol. 2014 Apr:66:76-88. doi: 10.1016/j.fct.2014.01.030. Epub 2014 Jan 24.

Authors

M Molin¹, S M Ulven², L Dahl³, W Goessler⁴, D Fliegel⁵, M Holck⁶, J J Sloth⁷, A Oshaug⁸, J Alexander⁹, H M Meltzer¹⁰, T A Ydersbond¹¹

Affiliations

¹ Department of Health, Nutrition and Management, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, P.O. Box 4, St. Olavs Plass, NO-0130 Oslo, Norway; Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, P.O. Box 1110, Blindern, NO-0317 Oslo, Norway; Atlantis Medical University College, P.O. Box 4290 Nydalen, N-0402 Oslo, Norway. Electronic address: molinmarianne@gmail.com.
² Department of Health, Nutrition and Management, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, P.O. Box 4, St. Olavs Plass, NO-0130 Oslo, Norway. Electronic address: sulven@hioa.no.
³ National Institute of Nutrition and Seafood Research, P.O. Box 2029 Nordnes, N-5817 Bergen, Norway. Electronic address: Lisbeth.Dahl@nifes.no.
⁴ Institute for Chemistry-Analytical Chemistry, Stremayrgasse 16, 8010 Graz, Austria. Electronic address: walter.goessler@uni-graz.at.
⁵ National Institute of Nutrition and Seafood Research, P.O. Box 2029 Nordnes, N-5817 Bergen, Norway. Electronic address: Daniel.Fliegel@tine.no.
⁶ Department of Health, Nutrition and Management, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, P.O. Box 4, St. Olavs Plass, NO-0130 Oslo, Norway. Electronic address: marianneholck@yahoo.no.
⁷ National Institute of Nutrition and Seafood Research, P.O. Box 2029 Nordnes, N-5817 Bergen, Norway; National Food Institute, Technical University of Denmark, DK-2860 Søborg, Denmark. Electronic address: jjsl@food.dtu.dk.
⁸ Department of Health, Nutrition and Management, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, P.O. Box 4, St. Olavs Plass, NO-0130 Oslo, Norway. Electronic address: arne.oshaug@hioa.no.
⁹ Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, N-0403 Oslo, Norway. Electronic address: Jan.Alexander@fhi.no.
¹⁰ Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, N-0403 Oslo, Norway. Electronic address: Helle.Margrete.Meltzer@fhi.no.
¹¹ Statistics Norway, P.O. Box 8131 Dep, N-0033 Oslo, Norway. Electronic address: Trond.Arild.Ydersbond@ssb.no.

PMID: 24468672
DOI: 10.1016/j.fct.2014.01.030

Abstract

The excretion pattern of arsenic (As) species after seafood intake varies widely depending on species ingested and individual handling. We have previously reported the 72 h urinary excretion of arsenicals following a single dose of seafood. Here, we report the excretion patterns in the same 37 subjects following 15 days daily consumption of either 150 g cod, salmon, blue mussels or potato (control), followed by a 72 h period with a low-As diet. In all seafood groups, total As (tAs) in plasma and urinary excretion of tAs, arsenobetaine (AB) and dimethylarsinate (DMA) increased significantly after the intervention. Confirming the single dose study AB and DMA excreted were apparently endogenously formed from other arsenicals ingested. Total tAs excretion was 1386, 763 and 303 μg in the cod, blue mussel and salmon groups, respectively; about twice the amounts after the single dose study indicating accumulation of arsenicals. In the cod group, rapid excretion after the single dose was associated with lower total As in blood and less accumulation after two weeks with seafood indicating lower accumulation. In the blue mussels group only, inorganic As (iAs) excretion increased significantly, whilst methylarsonate (MA) strongly increased, indicating a possible toxicological concern of repeated mussel consumption.

Keywords: Arsenic; Dietary intervention; Human; Methylarsonate; Seafood safety; Speciation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Arsenicals / blood
Arsenicals / urine*
Case-Control Studies
Diet*
Female
Humans
Male
Seafood*
Young Adult

Substances

Arsenicals