We developed a novel simple microwell plate that allows researchers to culture cells on chips easily without the use of tubes and pumps for studies of cell proliferation, apoptosis and pharmacology. Unlike any other previous design, this device can be put into an incubator directly and maintains cells in an environment with stable temperature, humidity, air pressure, oxygen and CO2 concentration. We cultured PC-12 cells in these microwell plates and measured the cell proliferation and apoptosis. The microwell plate is recommended for use in all research including those involving rare samples and expensive reagents.