Maternal antibodies by passive immunization with formalin inactivated respiratory syncytial virus confer protection without vaccine-enhanced disease

Antiviral Res. 2014 Apr:104:1-6. doi: 10.1016/j.antiviral.2014.01.008. Epub 2014 Jan 23.

Abstract

Maternal immunization of mice with formalin inactivated respiratory syncytial virus (FI-RSV) resulted in the passive transfer of RSV antibodies but not cellular components to the offspring. The offspring born to FI-RSV immunized mothers showed serum RSV neutralizing activity, effectively controlled lung viral loads without vaccine-enhanced disease, did not induce pulmonary eosinophilia, and cytokine producing cells after live RSV infection. Therefore, this study provides evidence that maternal immunization provides an in vivo model in investigating the roles of antibodies independent of cellular components.

Keywords: FI-RSV; Maternal antibodies; Passive immunization; Vaccine enhanced disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Viral / immunology*
  • Cytokines / biosynthesis
  • Female
  • Immunity, Maternally-Acquired*
  • Lung / immunology
  • Lung / pathology
  • Lung / virology
  • Mice
  • Respiratory Syncytial Virus Infections / immunology
  • Respiratory Syncytial Virus Infections / pathology
  • Respiratory Syncytial Virus Infections / prevention & control*
  • Respiratory Syncytial Viruses / immunology*
  • Vaccines, Inactivated / immunology*
  • Viral Vaccines / immunology*

Substances

  • Antibodies, Viral
  • Cytokines
  • Vaccines, Inactivated
  • Viral Vaccines