Hepatitis B virus X increases immune cell recruitment by induction of chemokine SDF-1

Hyun Kook Cho; So Young Kim; Je Kyung Seong; JaeHun Cheong

doi:10.1016/j.febslet.2014.01.017

Hepatitis B virus X increases immune cell recruitment by induction of chemokine SDF-1

FEBS Lett. 2014 Mar 3;588(5):733-9. doi: 10.1016/j.febslet.2014.01.017. Epub 2014 Jan 23.

Authors

Hyun Kook Cho¹, So Young Kim¹, Je Kyung Seong², JaeHun Cheong³

Affiliations

¹ Department of Molecular Biology, Pusan National University, Busan 609-735, Republic of Korea.
² Laboratory of Developmental Biology and Genomics, College of Veterinary Medicine, Interdisciplinary Program for Bioinformatics, and Program for Cancer Biology, Seoul National University, Seoul, Republic of Korea.
³ Department of Molecular Biology, Pusan National University, Busan 609-735, Republic of Korea. Electronic address: molecule85@pusan.ac.kr.

PMID: 24462680
DOI: 10.1016/j.febslet.2014.01.017

Abstract

Hepatitis B virus X protein is a major factor in the HBV-induced disease developments. Stromal cell-derived factor-1 is a small cytokine that is strongly chemotactic for lymphocytes. We explored the role of HBx on recruitment of HBV-induced virus-nonspecific immune cells into liver. Immune cell recruitment and SDF-1 expression level significantly increased in livers of HBx-transgenic mice and X-box binding protein-1 significantly increased SDF-1 gene expression. Finally, we confirmed that immune cell recruitment into liver tissues of HBx-TG mice was diminished by a chemokine receptor antagonist. Therefore, HBx increases ER stress-dependent SDF-1 expression and induces HBV-induced immune cell recruitment into liver.

Keywords: ER stress; HBx; Immune cell recruitment; SDF-1; XBP1.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cells, Cultured
Chemokine CXCL12 / genetics
Chemokine CXCL12 / metabolism*
DNA-Binding Proteins / physiology
Endoplasmic Reticulum Stress
Gene Expression
Hepatitis B virus / immunology*
Leukocytes, Mononuclear / immunology
Leukocytes, Mononuclear / virology
Liver / immunology
Liver / virology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Receptors, CXCR4 / metabolism
Regulatory Factor X Transcription Factors
Signal Transduction
Trans-Activators / physiology*
Transcription Factors / physiology
Transcriptional Activation*
Viral Regulatory and Accessory Proteins
X-Box Binding Protein 1

Substances

CXCR4 protein, mouse
Chemokine CXCL12
Cxcl12 protein, mouse
DNA-Binding Proteins
Receptors, CXCR4
Regulatory Factor X Transcription Factors
Trans-Activators
Transcription Factors
Viral Regulatory and Accessory Proteins
X-Box Binding Protein 1
Xbp1 protein, mouse
hepatitis B virus X protein