Pleural epithelioid hemangioendothelioma harboring CAMTA1 rearrangement

Lung Cancer. 2014 Mar;83(3):411-5. doi: 10.1016/j.lungcan.2013.12.015. Epub 2014 Jan 7.

Abstract

Pleural epithelioid hemangioendothelioma (EHE) is a very rare disease with adverse clinical outcomes. Recently, CAMTA1 rearrangement has been introduced as a consistent genetic abnormality in EHEs of different anatomical locations. We report a 71-year-old man with pleural EHE harboring CAMTA1 rearrangement confirmed by fluorescence in situ hybridization on paraffin embedded tissue.

Keywords: CAMTA1; EHE; Epithelioid hemangioendothelioma; FISH; Lung; Pleura.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Calcium-Binding Proteins / genetics*
  • Gene Rearrangement / genetics
  • Hemangioendothelioma, Epithelioid / diagnosis*
  • Hemangioendothelioma, Epithelioid / genetics*
  • Hemangioendothelioma, Epithelioid / pathology
  • Humans
  • In Situ Hybridization, Fluorescence*
  • Male
  • Pleural Neoplasms / diagnosis*
  • Pleural Neoplasms / genetics*
  • Pleural Neoplasms / pathology
  • Prognosis
  • Trans-Activators / genetics*

Substances

  • CAMTA1 protein, human
  • Calcium-Binding Proteins
  • Trans-Activators