Abstract
High-throughput sequencing of RNAs crosslinked to Argonaute proteins reveals not only a multitude of atypical miRNA binding sites but also of miRNA targets with atypical functions, and can be used to infer quantitative models of miRNA-target interaction strength.
MeSH terms
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Animals
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Argonaute Proteins / genetics
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Argonaute Proteins / metabolism*
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Binding Sites / genetics
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High-Throughput Nucleotide Sequencing / methods
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Humans
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Immunoprecipitation / methods*
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MicroRNAs / genetics*
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RNA, Untranslated / genetics
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Sequence Analysis, RNA / methods*
Substances
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Argonaute Proteins
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MicroRNAs
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RNA, Untranslated