Seq and CLIP through the miRNA world

Genome Biol. 2014 Jan 25;15(1):202. doi: 10.1186/gb4151.

Abstract

High-throughput sequencing of RNAs crosslinked to Argonaute proteins reveals not only a multitude of atypical miRNA binding sites but also of miRNA targets with atypical functions, and can be used to infer quantitative models of miRNA-target interaction strength.

Publication types

  • Review

MeSH terms

  • Animals
  • Argonaute Proteins / genetics
  • Argonaute Proteins / metabolism*
  • Binding Sites / genetics
  • High-Throughput Nucleotide Sequencing / methods
  • Humans
  • Immunoprecipitation / methods*
  • MicroRNAs / genetics*
  • RNA, Untranslated / genetics
  • Sequence Analysis, RNA / methods*

Substances

  • Argonaute Proteins
  • MicroRNAs
  • RNA, Untranslated